Valproic Acid: A Potential Therapeutic for Spinal Cord Injury.

This report reviewed the correlation between mTOR and autophagy, as well as autophagy's role and the therapeutic effects of VPA in SCI. VPA regulates autophagy by potentially inhibiting mTORC1, a complex of mTOR, while also hindering inflammatory response. Conclusively, an effective treatment for SCI could lie in the timely regulation of mTOR signaling pathway, and VPA could be the potential drug that improves SCI owing to its propensity to regulate the mTOR signaling pathway.
PMID: 32725456 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Neurobiology - July 27, 2020 Category: Cytology Authors: Zhou C, Hu S, Botchway BOA, Zhang Y, Liu X Tags: Cell Mol Neurobiol Source Type: research