Optimized blood culture strategy to document febrile neutropenia.

CONCLUSIONS: Bacteremia detection was improved. This proof-of-concept study shows benefits of combining the single-sampling strategy with large weight-adapted blood sampling strategy during EFN.
IMPACT: Combination of single-sampling and weight-adapted blood culture strategies showed benefits in the documentation of bloodstream infections during febrile neutropenia.Bacteremia detection was improved in this preliminary study and this warrants further evaluation in the overall pediatric population.We observed no adverse effects associated with the new strategy while overall blood sparing was improved and handling of intravascular devices was reduced.The good tolerance of the blood sampling suggests that the recommended 1% volume limitation in children could be reconsidered.A similar evaluation is justified in the overall pediatric population suspected for bloodstream infection.
PMID: 32722662 [PubMed - as supplied by publisher]

Source: Pediatric Research - July 27, 2020 Category: Pediatrics Authors: Lamy B, Dutron S, Haouy S, Saumet L, Marchandin H, Sirvent N Tags: Pediatr Res Source Type: research