Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor-kappa B (NF-?B) pathway.
CONCLUSION: Lycopene increases the sensitization of cervical cancer cells to cisplatin via inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression. Furthermore, anticancer effect of lycopene might be also associated with suppression of NF-?B-mediated inflammatory responses, and modulation of Nrf2-mediated oxidative stress. The results of the present study suggest that lycopene and the concurrent cisplatin chemotherapy might have a role to improve the treatment of cervical cancer.
PMID: 32718121 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
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