Type I IFN signaling in T regulatory cells modulates chemokine production and myeloid derived suppressor cells trafficking during EAE.

This study demonstrates that signaling by type I IFNs in Tregs reduces their capacity to suppress chemokine production, with resultant alteration of the entire microenvironment of draining lymph nodes leading to enhancement of MDSC homing, and beneficial effects on disease outcome.
PMID: 32709481 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - July 20, 2020 Category: Allergy & Immunology Authors: Tanwar S, Oguz C, Metidji A, Dahlstrom E, Barbian K, Kanakabandi K, Sykora L, Shevach EM Tags: J Autoimmun Source Type: research