Metabolic Profiling of Human Gastric Cancer Cells Treated With Salazosulfapyridine.

CONCLUSIONS: Our results indicate that in cancer cells having a predominant glycolytic pathway, metabolomic analyses under hypoxic conditions enable the profiling of global metabolism. In addition, inhibiting the supply of nicotinamide adenine dinucleotide phosphate by blocking glycolysis is a potential treatment strategy for cancer, in addition to cystine blockade by salazosulfapyridine.
PMID: 32715923 [PubMed - in process]

Source: Technology in Cancer Research and Treatment - December 31, 2019 Category: Cancer & Oncology Authors: Takizawa K, Muramatsu K, Maruyama K, Urakami K, Sugino T, Kusuhara M, Yamaguchi K, Ono H, Kitagawa Y Tags: Technol Cancer Res Treat Source Type: research