Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations [Evolution]
Antibiotic resistance frequently evolves through fitness trade-offs in which the genetic alterations that confer resistance to a drug can also cause growth defects in resistant cells. Here, through experimental evolution in a microfluidics-based turbidostat, we demonstrate that antibiotic-resistant cells can be efficiently inhibited by amplifying the fitness costs associated with...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Sergey V. Melnikov, David L. Stevens, Xian Fu, Hui Si Kwok, Jin–Tao Zhang, Yue Shen, Jeffery Sabina, Kevin Lee, Harry Lee, Dieter Soll Tags: Biological Sciences Source Type: research