Baicalin induces Mrgprb2-dependent pseudo-allergy in mice.

We examined the allergenic effect of baicalin on RBL-2H3 cells and Mrgprb3-knockdown RBL-2H3 cells. Mrgprb2-expressing HEK293 cells and Mrgprb2-knockout mice were used to evaluate the role of Mrgprb2 in baicalin-induced allergy. Baicalin was found to dose-dependently induce pseudo-allergy both in vitro and in vivo. RBL-2H3 cells were activated by baicalin, whereas in Mrgprb3-knockout RBL-2H3 cells, baicalin showed a negligible effect on cell activation. Furthermore, baicalin activated the Mrgprb2-expressing HEK293 cells. Our data showed that baicalin did not induce allergy in Mpgprb2-knockout mice. We conclude that baicalin induces pseudo-allergy via Mrgprb2 in mice. PMID: 32707128 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32707128?dopt=Abstract

Source: Immunology Letters - July 20, 2020 Category: Allergy & Immunology Authors: Wang J, Zhang Y, Che D, Zeng Y, Wu Y, Qin Q, Wang N Tags: Immunol Lett Source Type: research