A further step forward in our knowledge of the pathogenetic role of gastroesophageal reflux in pulmonary fibrosis

Pulmonary fibrosis is a repair response in lung tissue injury that involves loss of epithelial cells and accumulation of fibroblasts/myofibroblasts [1]. The main triggers of this fibrotic progression might be viral infections, organic and inorganic dusts, smoking and Gastroesophageal Reflux Disease (GERD). Furthermore, the majority of published studies have suggested that there is a strong comorbidity between GERD and Idiopathic pulmonary fibrosis (IPF) [2,3]. Based on this knowledge, we have read with interest the paper entitled “Stimulatory Effect of Gastroesophageal Reflux Disease (GERD) on Pulmonary Fibroblast Differentiation” written by Cheng et al [4].
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Commentary Source Type: research