Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis
DTX1 rs1732786A>G was associated with better prognosis in patients with early ‐stage non‐small cell lung cancer, in the previous study. DTX1 rs1732786A>G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer. Deltex ‐1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect ofDTX1 rs1732786A > G, which is associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC).DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26–0.66,P = 2 × 10−4; hazard ratio = 1.47, 95% CI: 1.17 –1.84,P = 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele (P = 2 × 10−7). In summary,DTX1 rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC.Key pointsSignificant findings of the studyDTX1 rs1732786A > G was associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC) in our previous study.What this study addsDTX1 rs1732786A > G was associated with a significantly worse chemotherapy response...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Seung Soo Yoo,
Jang Hyuck Lee,
Mi Jeong Hong,
Jin Eun Choi,
Hyo ‐Gyoung Kang,
Sook Kyung Do,
Ji Hyun Kim,
Sun Ah Baek,
Sun Ha Choi,
Won Kee Lee,
Yong Hoon Lee,
Hyewon Seo,
Jaehee Lee,
Shin Yup Lee,
Seung Ick Cha,
Chang Ho Kim,
Jae Yong P Tags: BRIEF REPORT Source Type: research
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