Knockdown of Bone Morphogenetic Protein Type II Receptor Leads to Decreased Aquaporin 1 Expression and Function in Human Pulmonary Microvascular Endothelial Cells.

In conclusion, decreased BMPR2 appears to affect Aqp1 at mRNA, protein, and functional levels. This observation may identify a contributory mechanism for PAH.
PMID: 32687728 [PubMed - as supplied by publisher]

Source: Canadian Journal of Physiology and Pharmacology - July 19, 2020 Category: Drugs & Pharmacology Authors: Vassiliou AG, Keskinidou C, Kotanidou A, Frantzeskaki F, Dimopoulou I, Langleben D, Orfanos SE Tags: Can J Physiol Pharmacol Source Type: research