NIH COVID-19 Lecture: COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far

NIH COVID-19 Lecture Series Since the outbreak of COVID-19 disease, caused by SARS-CoV-2 infection, many studies focusing on clinical course, outcome, clinical parameters, prognostic markers, treatment strategies have been published. Although most patients experience mild symptoms, some have serious complications — including diffuse alveolar damage, hemodynamic shock, acute kidney failure, cardiac injury, and arrhythmia — that contribute to the high mortality rate. Autopsies can offer a better understanding of the underlying pathophysiology. Unfortunately few autopsies were performed early in the pandemic because of the potential risks. Untreated patients who died of SARS-CoV-2 were rarely autopsied. Most of the published autopsy studies have focused on lung disease with a few describing findings in other organs. We will discuss our experience with the first set of patient autopsies performed at NYU Winthrop Hospital as well as some of our own experience here at the NIH. We will review some of the key findings in major organ systems accompanied by immunohistochemical and in situ hybridization studies that examined some of the cytokines/chemokines that have been implicated in the pathogenesis of this viral infection.Air date: 7/22/2020 3:00:00 PM
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