Corilagin suppresses RANKL-induced osteoclastogenesis and inhibits oestrogen deficiency-induced bone loss via the NF- κB and PI3K/AKT signalling pathways.

In conclusion, our findings suggested that Corilagin inhibited osteoclastogenesis by down-regulating the NF-κB and PI3K/AKT signalling pathways, thus showing its potential possibility for the treatment of osteoporosis.
PMID: 32681612 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - July 17, 2020 Category: Molecular Biology Authors: Lu J, Ye C, Huang Y, Huang D, Tang L, Hou W, Kuang Z, Chen Y, Xiao S, Yishake M, He R Tags: J Cell Mol Med Source Type: research