Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

We report potent anti-tumor effects of unacylated ghrelin, dependent on cells being cultured in 3D in a biologically-relevant extracellular matrix. The mechanism of unacylated ghrelin-mediated growth inhibition involves activation of G αi and suppression of MAPK signaling. AZP-531 also suppresses the growth of breast cancer cellsin vitro and in xenografts, and may be a novel approach for the safe and effective treatment of breast cancer.
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Source Type: research