Premature termination codons in the DMD gene cause reduced local mRNA synthesis [Genetics]

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene leading to the presence of premature termination codons (PTC). Previous transcriptional studies have shown reduced DMD transcript levels in DMD patient and animal model muscles when PTC are present. Nonsense-mediated decay (NMD) has been suggested to be responsible...

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Raquel Garcia–Rodriguez, Monika Hiller, Laura Jimenez–Gracia, Zarah van der Pal, Judit Balog, Kevin Adamzek, Annemieke Aartsma–Rus, Pietro Spitali Tags: Biological Sciences Source Type: research