Future and perspective of Zika virus: Drug repurposing as a powerful tool for treatment insights.

Future and perspective of Zika virus: Drug repurposing as a powerful tool for treatment insights. Mini Rev Med Chem. 2020 Jul 11;: Authors: Rampini D, Prieto DC, Colzi AL, de Araújo RV, Giarolla J Abstract The Zika virus (ZIKV) infection is a major public health concern in Brazil and worldwide, being a rapidly spreading disease with possible severe complications for pregnant women and neonates. There is currently no preventative therapy or specific treatment available. Within this context, drug repositioning is a very promising approach for the discovery of new treatment compounds, since old drugs may become new ones. Therefore, this paper aims to perform a literature mini-review to identify promising compounds to combat this virus. The mechanism of action at the molecular level and, when possible, the structure-activity relationship of prototypes are discussed. Among the candidates identified, we highlight sofosbuvir, chloroquine and suramine, which present a higher quantity of experimental data to draw on for our discussion. The current treatment is palliative, therefore, this study is of paramount importance in identifying drug candidates useful for combating ZIKV. PMID: 32651967 [PubMed - as supplied by publisher]
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research