Extrastriatal 123I-FP-CIT SPECT impairment in degenerative parkinsonisms

Neuropathological data and nuclear medicine imaging show extensive serotonergic impairment in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). The study aims at performing a case-controlled region-of-interest (ROI)-based analysis of 123I –N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (123I-FP-CIT) images to measure extrastriatal regional deficits in PD and APS, and assess their added diagnostic value in discriminating degenerative parkinsonisms from other conditions.

Source: Parkinsonism and Related Disorders - July 10, 2020 Category: Neurology Authors: Nicolas Nicastro, Vanessa Fleury, Nicolas Broc, Pierre R. Burkhard, Valentina Garibotto Source Type: research