Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer's disease: Amelioration by metabolic switching

Publication date: Available online 10 July 2020Source: International Review of NeurobiologyAuthor(s): Mark P. Mattson
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research

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In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the tr...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Although incurable, a staggering 40 per cent of cases could be prevented in the first place, according to a global report revealed at the Alzheimer's Association International Congress last week.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionsHowever, α‐MG (50 mg/kg) and XEFGM (100 mg/kg) reversed the cognitive impairment induced by CCH in MWM test. α‐MG (50 mg/kg) was further tested upon sub‐acute 14‐day treatment in CCH rats. Cognitive improvement was shown in MWM test but not in long‐term potentiation (LTP). BDNF but not CaMKII was found to be down‐regulated in CCH rats; however, both parameters were not affected by α‐MG. In conclusion, α‐MG ameliorated learning and memory deficits in both acute and sub‐acute treatments in CCH rats by improving the spatial learning but not hippocampal LTP. H...
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
AbstractTraumatic brain injury (TBI) and Alzheimer ’s disease (AD) are prominent neurological conditions whose neural and cognitive commonalities are poorly understood. The extent of TBI-related neurophysiological abnormalities has been hypothesized to reflect AD-like neurodegeneration because TBI can increase vulnerability to AD. However, it rema ins challenging to prognosticate AD risk partly because the functional relationship between acute posttraumatic sequelae and chronic AD-like degradation remains elusive. Here, functional magnetic resonance imaging (fMRI), network theory, and machine learning (ML) are levera...
Source: AGE - Category: Geriatrics Source Type: research
The gut microbiota is a complex ecosystem of bacteria, fungi, and viruses that acts as a critical regulator in microbial, metabolic, and immune responses in the host organism. Imbalances in the gut microbiota, termed “dysbiosis”, often induce aberrant immune responses, which in turn disrupt the local and systemic homeostasis of the host. Emerging evidence has highlighted the importance of gut microbiota in intestinal diseases, and more recently, in age-related central nervous systems diseases, e.g., stroke a nd Alzheimer's disease.
Source: Translational Research - Category: Research Authors: Tags: Review Article Source Type: research
One study of people with Alzheimer's found 81 per cent had either diabetes or raised blood sugar levels, known as prediabetes, which puts them on the cusp of developing the full-blown condition.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Yan Q, Wang W, Weng J, Zhang Z, Yin L, Yang Q, Guo F, Wang X, Chen F, Yang G Abstract Increasingly attention has been paid to the transdermal drug delivery systems with microneedles owing to their excellent compliance, high efficiency, and controllable drug release, therefore, become promising alternative with tremendous advantages for delivering specific drugs such as huperzine A (Hup A) for treatment of Alzheimer's disease (AD) yet with low oral bioavailability. The purpose of the present study is to design, prepare, and evaluate a dissolving microneedle patch (DMNP) as a transdermal delivery system for ...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
DISCUSSION: ICA promoted the proliferation and differentiation of Aβ25-35-treated hippocampal neural stem cells through BDNF-TrkB-ERK/Akt signaling pathway. The current findings might contribute to the treatment of AD. PMID: 32727295 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
CONCLUSION: The observed pharmacokinetic parameters of memantine of the test drug were similar to those of the reference formulation both in the fasting and fed state. That is to say, the test formulation of memantine 10-mg tablet is bioequivalent to the reference formulation (Ebixa 10-mg tablet). PMID: 32729819 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
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