Au speckled SPION@SiO2 nanoparticles decorated with thiocarbohydrates for ASGPR1 targeting towards HCC dual mode imaging potential application.

Au speckled SPION@SiO2 nanoparticles decorated with thiocarbohydrates for ASGPR1 targeting towards HCC dual mode imaging potential application.
Chemistry. 2020 Jul 06;:
Authors: Siciliano G, Corricelli M, Iacobazzi RM, Canepa F, Comegna D, Fanizza E, Del Gatto A, Saviano M, Laquintana V, Comparelli R, Mascolo G, Murgolo S, Striccoli M, Agostiano A, Denora N, Curri ML, Zaccaro L, Depalo N
Abstract
Efforts are made to perform an early and accurate detection of hepatocellular carcinoma (HCC) by simultaneous exploiting multiple clinically non-invasive imaging modalities. Original nanostructures derived from the combination of different inorganic domains can be used as efficient contrast agents in multimodal imaging.  Superparamagnetic nanoparticles (SPIONs) and Au nanoparticles (NPs) possess well-established contrasting features in magnetic resonance imaging (MRI) and X-Ray Computed Tomography (CT), respectively. HCC can be targeted by using specific carbohydrates able to recognize asialoglycoprotein receptor 1 (ASGPR1) overexpressed in hepatocytes. Here, two different thiocarbohydrate ligands were purposely designed and alternatively conjugated to the surface of Au speckled silica coated SPIONs NPs, to achieve two original nanostructures to be potentially used for dual mode targeted imaging of HCC. The results indicated that the two thiocarbohydrate decorated nanostructures possess convenient plasmonic/superparamagnetic properties, wel...

Source: Chemistry - July 5, 2020 Category: Chemistry Authors: Siciliano G, Corricelli M, Iacobazzi RM, Canepa F, Comegna D, Fanizza E, Del Gatto A, Saviano M, Laquintana V, Comparelli R, Mascolo G, Murgolo S, Striccoli M, Agostiano A, Denora N, Curri ML, Zaccaro L, Depalo N Tags: Chemistry Source Type: research