Cancers, Vol. 12, Pages 1827: Exosomal MicroRNAs and Organotropism in Breast Cancer Metastasis
Cancers, Vol. 12, Pages 1827: Exosomal MicroRNAs and Organotropism in Breast Cancer Metastasis
Cancers doi: 10.3390/cancers12071827
Authors:
Grace L. Wong
Sara Abu Abu Jalboush
Hui-Wen Lo
Breast cancer is the most frequent malignancy for women in which one in eight women will be diagnosed with the disease in their lifetime. Despite advances made in treating primary breast cancer, there is still no effective treatment for metastatic breast cancer. Consequently, metastatic breast cancer is responsible for 90% of breast cancer-related deaths while only accounting for approximately one third of all breast cancer cases. To help develop effective treatments for metastatic breast cancer, it is important to gain a deeper understanding of the mechanisms by which breast cancer metastasizes, particularly, those underlying organotropism towards brain, bone, and lungs. In this review, we will primarily focus on the roles that circulating exosomal microRNAs (miRNAs) play in organotropism of breast cancer metastasis. Exosomes are extracellular vesicles that play critical roles in intercellular communication. MicroRNAs can be encapsulated in exosomes; cargo-loaded exosomes can be secreted by tumor cells into the tumor microenvironment to facilitate tumor–stroma interactions or released to circulation to prime distant organs for subsequent metastasis. Here, we will summarize our current knowledge on the biogenesis of exosomes and miRNAs, mechanisms of cargo sorting i...
Source: Cancers - Category: Cancer & Oncology Authors: Grace L. Wong Sara Abu Abu Jalboush Hui-Wen Lo Tags: Review Source Type: research