Inflammatory Cell Infiltration of Adrenals in COVID-19
Horm Metab Res DOI: 10.1055/a-1191-8094Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated
in November–December 2019 in Wuhan, China, and has rapidly spread
around the world causing severe health and socioeconomical damage to the
entire civilization. The key feature of coronavirus disease 2019 (COVID-19),
caused by SARS-CoV-2, is upper respiratory tract infection, which may be
complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2)
has been identified as a key host factor, required for virus entry into
cells. Interestingly, ACE2 is expressed not only in the respiratory system,
but also in the other organs and systems including adrenal glands. Here we
provide the first description of the pathomorphological changes in adrenal
glands in patients with severe COVID-19 characterized by perivascular
infiltration of CD3+ and CD8+ T-lymphocytes. Due to the
central role of the adrenals in the stress response of the organism, this
finding is of potential clinical relevance, because infection with the
SARS-CoV-2 virus might critically impair adrenal function under
pathophysiological conditions. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Zinserling, Vsevolod A. Semenova, Natalya Yu. Markov, Alexander G. Rybalchenko, Oksana V. Wang, Jun Rodionov, Roman N. Bornstein, Stefan R. Tags: Immediate Interest Source Type: research
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