Synthesis and cellular effects of novel 1,3,5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines

This study provides new information on the cellular effects of 1,3,5-triazine nitrogen mustards with different peptide groups in DLD and Ht-29 human colon cancer cell lines. A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives bearing 2-chloroethyl and oligopeptide moieties was designed and synthesized. The most cytotoxic derivative was triazine with an Ala-Ala-OMe substituent on the ring (compound7b). This compound induced time- and dose-dependent cytotoxicity in the DLD-1 and HT-29 colon cancer cell lines. The triazine derivative furthermore induced apoptosis through intracellular signaling pathway attenuation. Compound7b may be a candidate for further evaluation as a chemotherapeutic agent against colorectal cancer.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

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Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
We report a case of synchronous double cancer of the prostate and ascending colon with metastases to multiple organs, including a large cardiac tumor. A 71-year-old Japanese man had prostate cancer with neck and para-aortic metastasis. He visited our hospital with complaints of fatigue and a positive fecal occult blood test result. Colonoscopy findings revealed the presence of a tumor in the ascending colon, and contrast-enhanced CT revealed a tumor in the heart, which was possibly due to metastasis from the ascending colon. The patient received palliative care and declined anticancer treatment. He died due to respiratory ...
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
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Source: Technology in Cancer Research and Treatment - Category: Cancer & Oncology Authors: Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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Source: Updates in Surgery - Category: Surgery Source Type: research
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Source: Surgical Endoscopy - Category: Surgery Source Type: research
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Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
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Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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