RAGE signaling pathway in Hippocampus Dentate Gyrus Involved in GLT-1 decrease Induced by Chronic Unpredictable Stress in Rats.

RAGE signaling pathway in Hippocampus Dentate Gyrus Involved in GLT-1 decrease Induced by Chronic Unpredictable Stress in Rats.
Brain Res Bull. 2020 Jul 01;:
Authors: Yang F, Wang H, Chen H, Ran D, Tang Q, Wong P, Sun Y, Jiang W
Abstract
A pivotal role of glutamatergic neurotransmission in the pathophysiology of major depressive disorder (MDD) has been supported in preclinical and clinical studies. Glutamate transporters are responsible for rapid uptake of glutamate to maintain glutamate homeostasis. Downregulation of glutamate transporters has been reported in MDD patients and animal models. However, the mechanism for stress-induced modulation of glutamate transporter expression is poorly understood. Receptor for advanced glycosylation end products (RAGE), a member of immunoglobulin family, is found expressed widely in brain and play important roles in neuronal development, neurite growth, neurogenesis and neuroinflammation. Our study showed chronic unpredictable stress (CUS) induced depressive-like behaviors and reduced RAGE expression in hippocampus DG, CA1 and CA3 areas. The protein levels of GLT-1, p-CREB and p-p65 decreased in hippocampus DG as well. Knockdown of RAGE expression in hippocampus DG with RAGE shRNA lentivirus particles induced depressive-like behaviors. Meanwhile, the protein and mRNA levels of GLT-1 were significantly decreased as well as phosphorylation of CREB and p65. Neither CUS nor RAGE knockdown altered GLA...

Source: Brain Research Bulletin - June 30, 2020 Category: Neurology Authors: Yang F, Wang H, Chen H, Ran D, Tang Q, Wong P, Sun Y, Jiang W Tags: Brain Res Bull Source Type: research