Generation of reactive oxygen species by hydroxypyridone compound/iron complexes.
Conclusion: Biological toxicity of mimosine and deferiprone reported previously can be accounted for by the prooxidant properties of hydroxypyridone compounds: coordination complex with iron generates reactive oxygen species resulting in the disturbance of mitochondrial energy metabolism and DNA damage.
PMID: 32615878 [PubMed - in process]
Source: Redox Report : communications in free radical research - Category: Biochemistry Authors: Murakami K, Yoshino M Tags: Redox Rep Source Type: research