Utilization of Diluted Compendial Media as Dissolution Test Solutions with Low Buffer Capacity for the Investigation of Dissolution Rate of Highly Soluble Immediate Release Drug Products.

This study indicated the importance of media buffer capacity as a factor inducing different dissolution between products of highly soluble active pharmaceutical ingredients. The diluted compendial media would be a useful alternative to biorelevant media for the detection of the different formulation performances depending on the buffer capacities. PMID: 32612001 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32612001?dopt=Abstract

Source: Chemical and Pharmaceutical Bulletin - July 3, 2020 Category: Drugs & Pharmacology Authors: Yoshida H, Abe Y, Tomita N, Izutsu KI Tags: Chem Pharm Bull (Tokyo) Source Type: research