Esmolol reduces myocardial injury induced by resuscitative endovascular balloon occlusion of the aorta (REBOA) in a porcine model of hemorrhagic shock

The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for the management of non-compressible torso hemorrhage is growing due to its ability to control hemorrhage and augment blood flow to the heart and brain. However, in addition to the profound ischemic injury to tissues below the level of aortic occlusion, recent evidence suggests that REBOA can cause injury to tissue beds proximal to the point of occlusion. Recent translational data has demonstrated direct myocardial injury as a result of complete aortic occlusion in a large animal model of hemorrhagic shock [1].

Source: Injury - July 1, 2020 Category: Orthopaedics Authors: Guillaume L Hoareau, Carl A Beyer, Connor M Caples, Marguerite W Spruce, Zachary Gilbert, J Kevin Grayson, Lucas P Neff, Timothy K Williams, M Austin Johnson Source Type: research