Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

Conclusion: These findings demonstrate that glutaminase inhibitors conjugated to dendrimers are a viable mechanism to selectively inhibit microglial GLS to reduce glutamate production and improve mobility in a mouse model of RTT, with broader implications for selectively targeting this pathway in other neurodegenerative disorders.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Elizabeth Smith Khoury, Anjali Sharma, Rajasekhar R Ramireddy, Ajit G. Thomas, Jesse Alt, Amanda Fowler, Rana Rais, Takashi Tsukamoto, Mary E. Blue, Barbara Slusher, Sujatha Kannan, Rangaramanujam M. Kannan Tags: Research Paper Source Type: research