In-Silico Factorial Screening and Optimization of Chitosan Based Gel for Urapidil Loaded Microparticle Using Reduced Factorial Design.

CONCLUSION: The principal of the study design was based on finding the prefixed set parameter values utilizing the concept of in-silico screening technique and optimization with a minimal number of trials and study expenses. It concluded that Poloxamer-188 (0.94%), chitosan (2.38%), swelling time (1.81 h), and parts of chitosan (78.51%) in a formulation batch would fulfil the predetermined parameter with specific values.
PMID: 32598248 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - June 27, 2020 Category: Chemistry Authors: Roy H, Nayak BS, Nandi S Tags: Comb Chem High Throughput Screen Source Type: research