CSF chitinase 3-like-1 association with disability of primary progressive MS

Conclusions This analysis supports the association between CSF CHI3L1 levels and neurologic disability according to EDSS scores in patients with PPMS. Other chitinase-like proteins such as CHI3L2 may also be involved. Classification of evidence This study provides Class II evidence that CSF CHI3L1 is associated with neurologic disability in patients with PPMS.

http://nn.neurology.org/cgi/content/short/7/5/e815?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - June 30, 2020 Category: Neurology Authors: Perez-Miralles, F., Prefasi, D., Garcia-Merino, A., Gascon-Gimenez, F., Medrano, N., Castillo-Villalba, J., Cubas, L., Alcala, C., Gil-Perotin, S., Gomez-Ballesteros, R., Maurino, J., Alvarez-Garcia, E., Casanova, B. Tags: Cerebrospinal Fluid, Multiple sclerosis, Cohort studies, Natural history studies (prognosis), Risk factors in epidemiology Article Source Type: research