Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients

ConclusionsOur data indicate that SOD1 mutation decreases miR-18b-5p, which sequentially regulates Hif1 α, Mef2c, miR-206, Mctp1 and Rarb in fALS-linked SOD1 mutation. These results provide new insights into the downregulation of miR-18b-5p dependent pathogenic mechanisms of ALS.

Source: Translational Neurodegeneration - June 30, 2020 Category: Neurology Source Type: research