Dual effects of S ‐adenosyl‐methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP+

Conclusions(1) SAM might induce neurotoxic or neuroprotective effects on PC12 cells, depending on the exposure conditions; (2) DNMT inhibitors might attenuate the MPP+ exacerbation toxicity induced by SAM; (3) DNA methylation might be involved in the observed effects of SAM (needs further investigation).

Source: Journal of Pharmacy and Pharmacology - June 28, 2020 Category: Drugs & Pharmacology Authors: Rebeca Araujo Cantelmo, Neife Aparecida G. Santos, Antonio Cardozo Santos, S âmia Regiane Lourenço Joca Tags: Research Paper Source Type: research