Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples

ConclusionsThis is, to the best of our knowledge, the first work systematically investigating inter- and intra-individual variations of SARS-CoV-2 using amplicon- and capture-based whole-genome sequencing, as well as the first comparative study among multiple approaches. Our work offers practical solutions for genome sequencing and analyses of SARS-CoV-2 and other emerging viruses.

Source: Genome Medicine - June 29, 2020 Category: Genetics & Stem Cells Source Type: research