Autophagy/virophagy: a "disposal strategy" to combat COVID-19.

Autophagy/virophagy: a "disposal strategy" to combat COVID-19. Autophagy. 2020 Jun 24;:1-2 Authors: Mijaljica D, Klionsky DJ Abstract Given the devastating consequences of the current COVID-19 pandemic and its impact on all of us, the question arises as to whether manipulating the cellular degradation (recycling, waste disposal) mechanism known as macroautophagy/autophagy (in particular, the selective degradation of virus particles, termed virophagy) might be a beneficial approach to fight the novel coronavirus, SARS-CoV-2. Knowing that "autophagy can reprocess everything", it seems almost inevitable that, sooner rather than later, a further hypothesis-driven work will detail the role of virophagy as a fundamental "disposal strategy" against COVID-19, yielding most needed therapeutic interventions. ABBREVIATIONS: ATG, autophagy-related; CoV/CoVs coronavirus/coronaviruses; COVID-19, coronavirus disease 2019; MERS-CoV, Middle East respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. PMID: 32578486 [PubMed - as supplied by publisher]
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research