MESP2 variants contribute to conotruncal heart defects by inhibiting cardiac neural crest cell proliferation

This study first analyzedMESP2 variants identified in sporadic nonsyndromic CTD patients.MESP2 is expressed in the OFT of different stages of human and mouse embryos.MESP2 regulates the transcriptional activities of downstream CTD-related genes and promotes CNCC proliferation by regulating cell cycle factorp21cip1 orCdk4.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research