Transfusional iron overload in patients with myelodysplastic syndromes: A 10-year retrospective survey from a French general hospital.

Transfusional iron overload in patients with myelodysplastic syndromes: A 10-year retrospective survey from a French general hospital. Transfus Clin Biol. 2020 Jun 16;: Authors: Bauduer F, Recanzone H Abstract We retrospectively assessed the characteristics of 165 MDS patients from our institution having received at least 20 RBC units. In the vast majority of them various comorbidities (range: 1-6 per patient) were registered including mainly cardiovascular disorders. Serum ferritin was over 1000 µg/L in about half of tested individuals. A chelator agent was initiated in 43.6% of patients (mainly low-risk MDS). Transformation in AML occurred in 46 cases (27.8%). Overall, 112 patients died during follow up. The cause of death was documented in 65 cases and included mainly MDS or AML resistance to therapy. There was a context of bacterial or fungal-related sepsis in 35.3% of cases. We noticed a correlation between survival and number of RBC transfusions. Median OS from the 20th RBC unit was significantly prolonged among the chelated subgroup. Consequences of transfusional iron overload and chelation need to be clarified in MDS patients. PMID: 32561328 [PubMed - as supplied by publisher]
Source: Transfusion Clinique et Biologique - Category: Hematology Authors: Tags: Transfus Clin Biol Source Type: research