Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction

Macrophages and neutrophils are primary leukocytes involved in the inflammatory response to myocardial infarction (MI). While interleukin (IL)-4 is an in vitro anti-inflammatory stimulus, the MI myocardium does not express a considerable amount of IL-4 but does express IL4 receptors. We hypothesized that continuous exogenous IL-4 infusion starting 24  h after MI would promote a polarization switch in inflammatory cells towards a reparative phenotype.

Source: Journal of Molecular and Cellular Cardiology - June 19, 2020 Category: Cytology Authors: Michael J. Daseke, Mavis A.A. Tenkorang-Impraim, Yonggang Ma, Upendra Chalise, Shelby R. Konfrst, Michael R. Garrett, Kristine Y. DeLeon-Pennell, Merry L. Lindsey Source Type: research