Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer's Disease.

Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer's Disease. Curr Protein Pept Sci. 2020 Jun 15;: Authors: Singh M, Singh SP, Dubey PK, Rachana R, Mani S, Yadav D, Agarwal M, Agarwal S, Agarwal V, Kaur H Abstract Locating remedies for Alzheimer's disease (AD) is been majorly restricted by inefficiency to establish a definitive detection model for early stage diagnosis of pathological events. This current lapse in AD diagnosis also limits the therapeutic efficiency of the drugs, which might have been effective if given at the earlier stages of the disease. The indicated situation directs towards the burgeoned need for an effective biomarker technique that will help in early detection of AD and would be imminently useful to facilitate improved diagnosis and stimulate therapeutic trials. Till date the major biomarkers, specifically associated with AD detection may help in determining the early stage AD diagnosis and identifying alterations in cellular proteome, offering deeper insight into disease etiology. Currently existing multidisciplinary clinical diagnosis of AD is very tedious, expensive procedure and requires highly trained and skilled professionals who are rarely available outside the specialty clinics. Mutations in amyloid precursor protein (APP) or Presenilin 1 and 2 (PSEN1 and PSEN2) are some biomarkers acting as a critical check points for AD diagnosis. However, the presence of some associated biomark...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research