025 Extracellular vesicles induce STING-mediated proinflammatory cytokines in Dermatomyositis

Dermatomyositis (DM) is an acquired inflammatory myopathy characterized by chronic skin inflammation. The pathogenesis of DM is still unclear. Extracellular vesicles (EVs) are lipid bilayer membrane vesicles existing in various bodily fluids and implicated in the pathogenesis of autoimmune diseases. As type I interferons, specifically IFN-b, are uniquely elevated in DM, and Stimulator of interferon genes (STING) works as a critical sensor and adaptor in type I IFN signaling, we hypothesized that EVs derived from DM patients ’ plasma might trigger STING-mediated proinflammatory effects.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research