Predicting the Malignant Transformation of Oral Submucous Fibrosis Using Quantitative Biomarkers p63 and CD31

Conclusion: A significant linear increase in nuclear staining of p63 and involvement of epithelial strata observed from Ea → MA → Ad grade of OSMF. CD31 expression exhibited more dilated vessels as OSMF grade increased from Ea → Ad. Therefore p63 and CD31 could be used as quantitative predictive biomarkers of malignant transformation of OSMF.

Source: Journal of Orofacial Sciences - June 11, 2020 Category: Dentistry Authors: Radhika Manoj Bavle Konda Paremala Makarala Sowmya Muniswamappa Sudhakara Venugopal Reshma Sreelatha Hosthor Source Type: research