Application of single-cell RNA sequencing on human skin: Technical evolution and challenges

Recent advances in molecular biology, particularly next-generation sequencing (NGS) technologies, have enabled development of targeted therapies for many skin disorders with high disease burden. For example, genetic linkage analysis and transcriptome profiling, such as interleukin (IL)-23 and T helper 17 profiles in psoriasis, IL-4 and IL-13 signatures in atopic dermatitis (AD), and aberrant JAK-STAT activation in alopecia areata, have defined core pathogenic processes for which successful therapeutics were developed [1].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Invited Review Article Source Type: research