Expert Panel: Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid (Day 2)

The National Toxicology Program (NTP) and Office of Dietary Supplements (ODS) are convening an expert panel to identify research needs related to the safe use of high intakes of folic acid based on consideration of the state of the science. The expert panel meeting will bring together experts from multiple disciplines including, but not limited to, epidemiology, nutrition, medicine, and toxicology. In preparation for this evaluation, screening of the literature was undertaken to identify potential adverse health effects for which further research might be warranted. A literature review document is being prepared on four health outcome areas using systematic review methodology: (1) cancer, (2) cognition in conjunction with vitamin B12, (3) hypersensitivity-related outcomes, and (4) endocrine and metabolic outcomes. The literature review document should be available by April 6, 2015, and will be posted to http://ntp.niehs.nih.gov/go/730864. A document describing the approach for conducting the literature evaluation has also been prepared and is posted on the NTP Website (http://ntp.niehs.nih.gov/ntp/ohat/folicacid/ntpfolicacid_approach_508.pdf). This document describing the approach includes information on the dose levels of folic acid being considered for the evaluation.For more information go to http://ntp.niehs.nih.gov/go/730864Air date: 5/12/2015 8:00:00 AM
Source: Videocast - All Events - Category: Journals (General) Tags: Upcoming Events Source Type: video

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Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Nae Yu Kim, Jung-Soo Pyo, Dong-Wook Kang, Seung-Min YooAbstractObjectiveThe aim of this study was to elucidate the clinicopathological significance and prognostic role of loss of claudin-1 in colorectal cancer (CRC).MethodsThe correlations between claudin-1 expression and clinicopathological characteristics, including survival rates, were assessed using immunohistochemistry on 260 archival, paraffin-embedded CRC tissues. In addition, the correlations between cludin-1 and nuclear factor-kappa B (NF-κB), epithelial-mes...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This study investigated the possibility of using umbilical cord mesenchymal stem cells (MSCs) as cellular carriers of IFN-β.Isolated umbilical cord MSCs were transfected with a lentivirus packaging IFN-β-overexpression plasmid. A549 cells were subcutaneously injected into nude mice to establish a non-small cell lung cancer (NSCLC) mouse model. A total of 50 mice were randomly assigned to 5 different groups: a control group, IFN-β group, IFN-β-MSCs group, MSCs-lentivirus group, and MSCs group. Next, the IFN-β-MSCs, MSCs-lentivirus, and MSCs were injected into the A549 lung cancer-bearing mice in the...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Cong-Cong Wu, Zhi-Jun SunAbstractExpression of the family with sequence similarity 3 member C (FAM3C) is necessary for the epithelial-mesenchymal transition (EMT). However, the expression level and clinicopathological significance of FAM3C in oral squamous cell carcinoma (OSCC) has not been thoroughly elucidated to date. We performed immunohistochemical staining on human OSCC specimens with FAM3C, co-inhibitory immune checkpoints, EMT markers, and cancer stem cells (CSCs) markers to analyze the expression levels and clinic...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Xin Gong, Xiaoyun Liao, Mengyi HuangAbstractIncreasing evidence reveal the important role of long non-coding RNAs (lncRNAs) in the initiation and progression of glioma. However, the role of lncRNA cancer susceptibility candidate 7 (CASC7) in glioma is largely unknown. At first, the expression level of CASC7 was tested in glioma tissues and cell lines by using qRT-PCR. We applied Kaplan-Meier method to analyze the correlation between the expression level between CASC7 expression and the overall survival rate of glioma patie...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Shun Wang, Jun Jiang, Chao Zhang, Xuhua Zhang, Chuanxin WangAbstractBackgroundLincRNA-p21 is involved in the initiation and progression of many human diseases. We aimed to investigate the expression of LincRNA-p21 in different types of liver diseases.MethodsSerum from patients with primary liver diseases (chronic HBV or HCV infection, hepatitis B virus-related cirrhosis, hepatitis B virus-related HCC, non-HBV/HCV-related HCC, alcoholic liver disease) and HBV negative liver metastatic cancer and control healthy individuals ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Aili Tan, Ruoyu Luo, Peng RuanAbstractEndometrial cancer (EC) is a huge threat to women’s health. The aims of this study were to investigate the role of microRNA (miR)-495 in the proliferation and apoptosis of EC cells in vitro. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to detect the mRNA levels. In addition, dual-luciferase reporter assay was used to verified that PIK3R1 was a target of miR-495. After transfection with miR-495 mimics, Cell Counting Kit 8 (CCK-8) assay was p...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsLncRNA BLACAT1 contributes to the proliferation and migration of OS cells by regulating STAT3.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusion: Sexuality is overlooked in the care of cancer patients. Multidisciplinary care in oncology has to acknowledge this situation and implement, in a joint action, educational and psychosocial support activities so this basic human need is met.
Source: Acta Paulista de Enfermagem - Category: Nursing Source Type: research
Cancer-fighting Five Prime Therapeutics Inc. will cut about 20 percent of its 209-person workforce as it tries to push more drugs into clinical trials and advance those already being tested on patients. The move — the first large-scale layoff in the South San Francisco biotech company's 17 years — comes during a sustained push by Five Prime (NASDAQ: FPRX) into cancer immunotherapy, where drugs are used to rally the immune system to battle cancer. The job cuts, starting today, include researc h,…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
This study aimed to investigate the role of the PD-L1/PD-1 pathway in oral squamous cell carcinoma (OSCC) and oral epithelial precursor lesions (OEPL).Materials and methodsWe examined 106 OSCC and 79 OEPL specimens for PD-L1 and PD-1 expression by immunohistochemistry. The results were compared with clinicopathological features of OSCC patients.ResultsIn OSCC and OEPL specimens, PD-L1 expression was detected predominantly in epithelial or carcinoma cells, whereas PD-1 expression was found mainly in infiltrating or stromal lymphocytes. Seventy-two OSCC (67.9%) and 21 OEPL (26.6%) specimens were positive for PD-L1, and 73 OS...
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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