Expert Panel: Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid (Day 2)

The National Toxicology Program (NTP) and Office of Dietary Supplements (ODS) are convening an expert panel to identify research needs related to the safe use of high intakes of folic acid based on consideration of the state of the science. The expert panel meeting will bring together experts from multiple disciplines including, but not limited to, epidemiology, nutrition, medicine, and toxicology. In preparation for this evaluation, screening of the literature was undertaken to identify potential adverse health effects for which further research might be warranted. A literature review document is being prepared on four health outcome areas using systematic review methodology: (1) cancer, (2) cognition in conjunction with vitamin B12, (3) hypersensitivity-related outcomes, and (4) endocrine and metabolic outcomes. The literature review document should be available by April 6, 2015, and will be posted to A document describing the approach for conducting the literature evaluation has also been prepared and is posted on the NTP Website ( This document describing the approach includes information on the dose levels of folic acid being considered for the evaluation.For more information go to date: 5/12/2015 8:00:00 AM
Source: Videocast - All Events - Category: Journals (General) Tags: Upcoming Events Source Type: video

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Publication date: September 2018Source: Nano Energy, Volume 51Author(s): Jun Li, Lei Kang, Yanhao Yu, Yin Long, Justin J. Jeffery, Weibo Cai, Xudong WangAbstractImplantable nanogenerator (i-NG) has shown great promises for enabling self-powered implantable medical devices (IMDs). One essential requirement for practical i-NG applications is its long-term bio-compatibility and bio-safety. This paper presents a systematic study of polydimethylsiloxane (PDMS) and PDMS/Parylene-C packaged polyvinylidene fluoride (PVDF) NGs implanted inside female ICR (Institute of Cancer Research) mice for up to six months. The PVDF NG had a st...
Source: Nano Energy - Category: Nanotechnology Source Type: research
Publication date: Available online 21 July 2018Source: Seminars in Cell &Developmental BiologyAuthor(s): Jiayun Hou, Xiangdong WangAbstractPolycomb group proteins (PcG) play important roles in the maintenance of DNA sequencing and multi-dimensional organization of genome. The main PcG complexes are consisted of Polycomb repressive complex 1 and 2, of which the diversity is dependent upon target gene sequences and functions. The present review initially explores the mechanism-based relationship and functional roles of PcG proteins in the interplay between epithelial mesenchymal transition (EMT) and chromatin dynamics in...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
In this study, we found that overexpression of nicotinamide nucleotide transhydrogenase (NNT) was associated with shorter overall and disease free survival in gastric cancer. The NNT is considered a key antioxidative enzyme based on its ability to regenerate NADPH from NADH. Knockdown of NNT caused significantly NADPH reduction, induced high levels of ROS and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis. In vivo experiments showed that NNT promoted tumor growth, lung metastasis and peritoneal dissemination of gastric cancer. Moreover, intratumoral injection of NNT siRNA ...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 21 July 2018Source: Chemico-Biological InteractionsAuthor(s): Bharath Kumar VelmuruganAbstractThe psychoactive properties of cannabinoids are well known and there has been a continuous controversy regarding the usage of these compounds for therapeutic purposes all over the world. Their use for medical and research purposes are restricted in various countries. However, their utility as medications should not be overshadowed by their negative physiological activities. This review article is focused on the therapeutic potential and applications of phytocannabinoids and endocannabinoids. It h...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
BOWEL cancer symptoms include stomach pain, a change in bowel habits, and finding blood in your stool. You could reveal your risk of cancer by thinking about how often you use the toilet. How many toilet trips counts as a ‘normal’ amount?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 21 July 2018Source: Seminars in Cancer BiologyAuthor(s): Jinsong LiuAbstractLife starts with a zygote which is formed via fusion of haploid sperm and egg. The formation of blastomere via cleavage division (nuclear division without increase in cell size) is the first step in the embryogenesis after zygote. The blastomeres are responsible to reprogram parental genome to new embryonic genome for generation of pluripotent stem cells which then differentiate via Waddington’s epigenetic landscape to give a birth for a new life. Multiple authors over the past century and a half have propos...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 July 2018Source: Journal of Chemical NeuroanatomyAuthor(s): Sabita Neupane, Sunil Srivastav, Sunil Bhurtel, Nikita Katila, Sina Shadfar, Pil-Hoon Park, Jin Tae Hong, Dong-Young ChoiAbstractIL-32 is a proinflammatory cytokine, and involved in various diseases including infection, inflammation, and cancer. However, effects of IL-32 on neuroinflammation remain obscure. Herein, we examined the effects of IL-32β on systemic LPS-induced neuroinflammation using IL-32β transgenic (Tg) mice. IL-32β wild type (WT) and Tg mice received LPS injection (5 mg/kg, i.p.), and then...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
ConclusionsIncreased proline concentrations can occur after administration of high-dose proline (as was the case here) or in the rare metabolic disorders hyperprolinema types I and II.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news
miR-140-5p inhibits the proliferation and enhances the efficacy of doxorubicin to breast cancer stem cells by targeting Wnt1, Published online: 22 July 2018; doi:10.1038/s41417-018-0035-0miR-140-5p inhibits the proliferation and enhances the efficacy of doxorubicin to breast cancer stem cells by targeting Wnt1
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
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