Primary Immune Deficiencies: Update on an Evolving Clinical Discipline

Every 2 years starting in the 1970s, the International Union of Immunological Societies publishes a list of human inborn errors of immunodeficiency and autoinflammatory disorders. The latest publication in January 2020 lists 416 inborn errors of immunity, including 64 gene defects identified in just the past 2 years since the previous update. The advances in molecular biology, especially next-generation sequencing, have contributed greatly to the rapid identification of novel gene defects. These advances have contributed greatly to our understanding of the immune system, and to a better understanding of the cellular, molecular, and immunologic mechanisms that lead to immune deficiency and autoinflammatory disorders.
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Tags: Preface Source Type: research