Early Results of a Management Algorithm for Collapsing Spine Deformity in Young Children (Below 10-Year Old) With Spinal Muscular Atrophy Type II

Conclusions: Short-term results indicate that MCGR may be a good option in SMA-associated collapsing spine deformity to reduce the burden of repetitive lengthening procedures. The authors recommend apical deformity control in the convex side in case of curve rigidity. In addition, including the pelvis in the instrumentation at index surgery is critical to prevent distal adding-on. Level of Evidence: Level IV—retrospective case series.
Source: Journal of Pediatric Orthopaedics - Category: Orthopaedics Tags: Early Onset Scoliosis Source Type: research

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Publication date: Available online 11 July 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chien-Chih Lai, Yi-Syuan Sun, Fang-Chi Lin, Chih-Yu Yang, Chang-Youh Tsai
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Authors: Massabeti R, Cipriani MS, Valenti I Abstract At the end of December 2019, the Health Commission of the city of Wuhan, China, alerted the World Health Organization (WHO) to a pneumonia cluster in the city. The cause was identified as being a new virus, later named SARS-CoV-2. We can distinguish three clinical phases of the disease with a distinct pathogenesis, manifestations and prognosis. Here, we describe the case of a 45-year-old male, successfully treated for Coronavirus disease (COVID-19). The patient was feeling sick in early April 2020; he had a fever and pharyngodynia. When he came to our COVID hosp...
Source: Journal of Population Therapeutics and Clinical Pharmacology - Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research
ConclusionsThe presentation of our patients raises the possibility that hypertrophic cardiomyopathy may be an additional feature of the clinical syndrome associated withUCHL1 mutations, and highlights the importance of cardiac follow-up and treatment in neurodegenerative disease associated withUCHL1 mutations.
Source: Journal of Neurology - Category: Neurology Source Type: research
Source: Reuters: Health - Category: Consumer Health News Source Type: news
Authors: Akkoc T Abstract On December 31, 2019, novel SARS-CoV2 spread from Wuhan China to more than 200 territories around world and the World Health Organization declared a COVID-19 pandemic on January 30, 2020. At this time there is no particular therapy, drug or vaccine available to deal with COVID-19. Today actual data indicates that about 17% of closed COVID-19 cases died. Health care professionals, ministry of health in countries and the public are trying to read the runes to see when the COVID-19 pandemic will be over. Although mild cases of COVID-19 can be controlled with antiviral, anti-inflammatory and i...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Basel, 12 June 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today presented two-year data from Part 1 of its pivotal SUNFISH trial in people aged 2-25 years with Type 2 or 3 spinal muscular atrophy (SMA) at the virtual Cure SMA Annual Conference, 8-12 June, 2020. The results of an exploratory efficacy analysis show risdiplam significantly improved motor function after 24 months of treatment compared to natural history data. In addition, preliminary 12 month data from JEWELFISH, a trial in people with all types of SMA aged 6 months to 60 years previously treated with other SMA therapies, showed that treatment with risdiplam le...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
ConclusionPediatric NMS patients undergoing PSF that have history of pneumonia or gastrostomy tube present at time of surgery are at increased risk for postoperative respiratory complications. The univariate associations of tracheostomy presence and low transferrin levels with postoperative respiratory complications deserve further examination.Level of EvidenceLevel II.
Source: Spine Deformity - Category: Orthopaedics Source Type: research
Conclusions: Definitive posterior spinal fusion for treatment of scoliosis associated with SMA is effective at controlling curve progression and pelvic obliquity without negatively impacting the space-available-for-lung ratio, trunk height, or pulmonary function at 10 years follow-up. Level of Evidence: Therapeutic Level IV.
Source: Journal of Pediatric Orthopaedics - Category: Orthopaedics Tags: Online Exclusive Spine Focus Section: Neuromuscular Spine Source Type: research
Conclusions:HRU in SMA focuses around respiratory support and care, with increasing orthopedic resource use driven by onset and management of scoliosis in older patients.Study Supported by: Funded by Biogen.Disclosure: Dr. Teynor has received personal compensation for activities with Biogen as an employee. Dr. Teynor holds stock/stock options in Biogen. Dr. Zhou has received personal compensation for activities with Biogen Idec. Dr. Zhou has received research support from Biogen Idec. Dr. Hou has received personal compensation for activities with Biogen as an employee. Dr. Wells has received personal compensation for activ...
Source: Neurology - Category: Neurology Authors: Tags: Child Neurology I Source Type: research
Conclusions:The generalizability of SMA patients treated at MDA clinics to all SMA patients requires further exploration. The MDA Registry is one of the largest clinic-based observational longitudinal cohorts of SMA patients in the US and is a valuable resource to describe and characterize SMA and its comprehensive clinical care.Study Supported by: BiogenDisclosure: Dr. Jones has received personal compensation for activities withBiogen as an employee. Dr. Jones holds stock and/or stock options in Biogen. Dr. Eaton has received personal compensation for activities with Biogen as an employee. Dr. Eaton holds stock and/or sto...
Source: Neurology - Category: Neurology Authors: Tags: Child Neurology II Source Type: research
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