Pan-Cancer Analysis of the Developmental Pathways Reveals Non-Canonical Wnt Signaling as a Driver of Mesenchymal-Type Tumors

The processes of angiogenesis, cell proliferation, invasion, and migration, and the signaling pathways that drive these events, are activated in both cancer and during embryonic development. Here, we systematically assessed how the activity of major developmental signaling pathways, represented by the expression of genes encoding components of the pathways, correlated with patient survival in ∼8000 patients across 17 cancer types. We also compared the expressed genes enriched in developmental pathways with those associated with epithelial-mesenchymal transition (EMT) both in a cancer cohort and in mice during embryonic development.
Source: Translational Research - Category: Research Authors: Source Type: research