O-GlcNAcase: emerging mechanism, substrate recognition and small molecule inhibitors.

This article also focuses on the catalytic mechanism and substrate recognition by OGA. In addition, we present an updated overview on small molecule OGA inhibitors, either of carbohydrate or noncarbohydrate scaffolds, regarding their structures, binding modes and selectivity towards the enzyme, and potential therapeutic outcomes in probing O -GlcNAcylation at cellular levels. This minireview is believed to be a good starting point to develop more potent and selective OGA drug candidates. PMID: 32496638 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research