F-18 fdg pet/mri in primary staging of breast cancer: the relationships between imaging parameters of primary tumor and distant metastases

Conclusions: Primary tumors of patients with IDC had higher metabolic and glycolytic activity, higher cellularity and larger sizes in multimetastatic state compared to the nonmetastatic and oligometastatic groups and in M-SM group compared to the IBM group. Tumor diameter, pretreatment CA 15-3 levels and molecular subtypes of tumors were found as significant predictors of FDG PET positivity for distant metastasis and extra-axillary LNs. Table 1. The characteristics of patientsAge (mean ± SD)51.3 ± 12 yearsTUMOR GRADE N (%)Grade 1: 35 (14%),Grade 2: 116 (46.4%),Grade 3: 99 (39.6%)MOLECULAR SUBTYPE N (%)Luminal A: 58 (22.5%),Luminal B (HER2 negative): 117 (45.3%),Luminal B (HER 2 positive): 35 (13.6%),HER2 Overexpressed: 18 (7.0%),Triple Negative: 30 (11.6%)METASTATIC STATUS N (%)Nonmetastatic group (M0): 193 (74.2%),Oligometastatic group: 25 (9.6%),Multimetastatic group: 42 (16.2%)THE TYPE OF DISTANT METASTASIS N (%)Isolated Bone Metastasis: 28 (41.8%),Mixed-Soft Tissue Metastasis: 39 (58.2%)FDG PET STATUS N (%)Positive: 78 (30%),Negative: 182 (70%)AXILLARY LN STATUS N (%)Negative: 76 (32.8%),Positive: 156 (67.2%)
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer I Source Type: research