Ablation Informed by Reconciliation of Stimulated Thyroglobulin and Post-Thyroidectomy Iodine Neck Uptake: Radiotheragnostic Management of Differentiated Thyroid Cancer.

Conclusion: We developed the methodology, 'Tulchinsky Tg/RAIU Reconciliation', for calculating maximum Tg that could be attributed to RBT under hormone withdrawal stimulation (maxTg-RBT), based on measured 24-hour RAIU over the thyroid bed. This method informs us with high level of specificity (97%) that patients have no occult DTC after TT when measured Tg is below the maxTg-RBT, and they are most suitable for remnant ablation. The inverse logical extrapolation (that requires further study/confirmation) is that patients whose Tg calculates above the maxTg-RBT may have metastatic or residual microscopic DTC; therefore, they may be more appropriately considered for adjuvant RAIT.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New Trends in Endocrine Therapy Source Type: research