Effect of reducing specific activity of [177Lu]-DKFZ-PSMA617 on uptake in the tumor, salivary gland and kidney

Conclusions: These studies establish that salivary gland and kidney uptake can be drastically reduced without affecting tumor uptake of 177Lu-PSMA617 simply by reducing its specific activity. These studies provide proof of concept solutions for xerostomia and renal toxicity arising from [177Lu]-PSMA617. References: Pillarsetty N, et al. J Nucl Med 2016 vol. 57 (supplement_2), 528.

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Kalidindi, T. M., Lee, S. G., Punzalan, B., Veach, D., Jou, K., Chakraborty, G., Tagawa, S., Bander, N., Lewis, J., Larson, S., Osborne, J., Pillarsetty, N. Tags: Basic Oncology & amp; Translational I Source Type: research