Generation and Characterization of the E µ-Irf8 mouse model

Chromosomal translocations are an integral part of cancer pathogenesis. In hematological malignancies, they play an outsized role and, as exemplified by the t(9;22) /BCR-ABL fusion, and t(15;17) /PML-RAR α fusion, these abnormalities can inform the disease biology, diagnosis and the development of rational therapies [1]. In mature B-cell malignancies, chromosomal translocation often lead to the juxtaposition of a “target” gene locus to the regulatory regions of the immunoglobulin heavy (IGH) or light chain loci [2].

Source: Cancer Genetics and Cytogenetics - June 1, 2020 Category: Genetics & Stem Cells Authors: Zhijun Qiu, Kenneth N. Holder, An-Ping Lin, Jamie Myers, Shoulei Jiang, Karla M. Gorena, Marsha C. Kinney, Ricardo C.T. Aguiar Tags: Original article Source Type: research