Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation

It has been established that UV irradiation induces DNA damage by forming dimers that can lead to cancer cell initiation [1]. UV also yields to tissue oxidative stress, inflammation and apoptosis pathways activation [2] [3]. There is no information if these events may generate compounds related to the proliferation or elimination of the cells that may contribute to tumor development. Oxidative stress generates 4- hidroxynonenal (4-HNE) involved in cell proliferation [4]. Also, it produces H2O2 that, direct or indirectly, activates NF κb leading to pro-inflammatory cytokines and nitric oxide synthase (iNOS) expression.

Source: Journal of Dermatological Science - June 1, 2020 Category: Dermatology Authors: Fernando Pinheiro Souza-Neto, Poliana Camila Marinello, Alessandra Louren ço Cecchini, Gabriela Pasqual Melo, Leandra Zambeli Naira Ramalho, Eliana M. Cela, Valeria E. Campo, Daniel H. González Maglio, Rubens Cecchini Tags: Letter to Editor Source Type: research