The effect of gonadectomy and angiotensin II receptor blockade in a mouse model of isoproterenol-induced cardiac diastolic dysfunction.

CONCLUSION: These gender differences suggest that sex hormones play a pivotal role in modulating cardiac hypertrophy and diastolic dysfunction induced by chronic beta-adrenoceptor stimulation, thereby affecting the therapeutic potential of angiotensin receptor blockade. PMID: 32475904 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32475904?dopt=Abstract

Source: Journal of Nippon Medical School - May 29, 2020 Category: Universities & Medical Training Authors: Asai K, Murai M, Shirakabe A, Kamiya M, Noma S, Sato N, Mizuno K, Shimizu W Tags: J Nippon Med Sch Source Type: research